Ewing's sarcoma, malignant bone tumor, bone pain in a child or adolescent

Health renblades July 27, 2016 0 54
A mainly during puberty, it is common bone cancer Ewing's sarcoma. From the bone material can by chromosomal abnormalities tumors are developed stimulated by growth hormones. It leads to aching bones, swelling, can not bend joints and weight loss. What is the Ewing's sarcoma, why should it be quickly identified and how is it treated?

Ewing's sarcoma

  • Chromosomal aberrations
  • How to recognize?
  • Extent of occurrence
  • Metastases
  • Treatment Pathway
  • Survival rate

Chromosomal aberrations

Most striking about the disease is that there is always an exchange of chromosomes. The number eleven and twenty-two chromosomes have swapped places, so that the body gets wrong instructions. This deviation is shown in nine out of ten cases. Or the gene mutation causes bones or bone formation are affected. A tumor can be done from the bone itself are developed, where in addition it may also occur in adjacent soft tissues. How chromosomal abnormality leads to bone cancer, was hitherto unknown.

How to recognize?

As with many types of cancer it is accompanied by several problems. Initially this will involve local bone pain, with surrounding tissues up. Especially if the malignancy is present near a joint, it gives movement problems. The joint hurts, swells and can bend tricky. Because the tumor from the bone develops, it will affect the structure of bone and weaken. The risk of fractures thereby increasing rapidly. Typical of cancer is that the person is excessively tired, sweat a lot during the night, eating little and thereby decreasing weight. The intensity of these symptoms vary by case, allowing the cancer initially is not recognized. For a good successful treatment is quick diagnosis is necessary, because metastases may apply. Does your child or adolescent teen strange symptoms with pain and weight loss then a medical examination is important.

Extent of occurrence

The disease is not common in our country. Every year it is a thirty to forty cases, most of which are young people. It is observed from five to thirty years, but in most cases it occurs during puberty. During this period, the child's body changes considerably, with a relatively high testosterone, estrogen, aromatase and calcitoninegehalte present. These stimulate the growth, production of muscle-specific sexual characteristics, as well as bone growth. In other words, the growth spurt encourages, in this case, increasing the formation of bone tumors. Despite the fact that it is relatively rare, it is the second most common bone cancer.


The longer the person walks around with it, the greater is the risk of metastasis. It is then often in other bones, but it can also cause lung cancer. Following the typical symptoms is diagnosed by MRI, X-ray ?? s, blood tests and taking a biopsy. The lungs are examined as well. Based on all the data a staging can be determined, based on which the treatment is determined. In a quarter of cases there is metastasis.

Treatment Pathway

The treatment is prolonged, whereby intensive chemotherapy is used. Initially involves four to five months of chemo, then surgery follows. The purpose is to explain the activity of existing cancer cells restricted. The distribution will be prevented, the tumor decreases and less persistent. After the removal of the tumor will be given for about half a year chemotherapy, sometimes combined with radiation in order to exclude recidivism. The intensive chemotherapy tandem is intended to neutralize all cancer cell activity. Obviously, following a lengthy aftercare to treat complications and complaints.

Survival rate

The treatment provides compared to previous methods, much more favorable odds. Approximately six out of ten cases can now recover completely. The extent to which they may or may not cure depends on the location of the bone tumor metastases off, and the extent of its application. In addition, the necessity that the cancer cells respond positively to chemotherapy. By case thus viewed it catches on to what extent and shape to the further treatment process. Let yourself be thoroughly informed by the pediatric about how the treatment is continued.