French Inserm researchers have developed a test that can determine when the oocytes are most likely to be fertilized.
In vitro fertilization is an assisted reproduction technique based on contacting an oocyte and sperm in the laboratory. This process is sometimes difficult to live for couples who can access it. To reduce the number of attempts which show a failure, a team of the National Institute of Health researchers worked on a test that can determine the IVF success rate. The test is based on a biological marker which is located in blood, the free DNA. This is DNA which comes from the stressed cells, degraded or lost for various reasons.
Women with high levels of free DNA in blood and in the fluid of ovarian follicles often have poor ovarian reserve and polycystic syndrome. They therefore unlikely to become pregnant. By cons, all follicles are not subject to the same amount of stress during their maturation leading to the release of an oocyte, the researchers from Inserm.
A blood test soon?
In this way, by analyzing the free DNA concentration of each oocyte collected before IVF, one can select the most favorable and calculate their chances of success. The result of this test seems reliable to 88%. "This should not discourage women. This marker varies in cycles and indicates a need to shift the attempt of two or three months to try to get better quality of oocytes," says Professor Samir Hamamah, responsible this work.
The researcher also uses this technique since 2011 and has managed to double the rate of births from assisted reproduction in his department, CHU Montpellier. The pharmaceutical industry would already seduced by the concept. The goal: to develop a blood test that can tell women the right cycle and to select the most favorable oocytes at fertilization.