Panmyelopathy or bone marrow aplasia

Health chichislover August 8, 2016 0 1
The name panmyelopathy is also known under the name of bone marrow aplasia or aplastic anemia. It is a disorder of the bone marrow which results in a decline in production of the white and red blood cells. As a result, there arises, among other anemia. There are two forms of this disease. The disease is very rare, but who once comes not just from. Fortunately treatment is possible but can not always be sufficient. This article will be chosen for the three different names for bone marrow aplasia.

What is bone marrow aplasia ie panmyelopathy?

Bone marrow aplasia sounds many people unfamiliar. That sounds about right, because this disease is very rare. 1 in 400.00 to 500,000 people develop this disease. However, the disease is more common in the temporary form in people who are exposed to certain medications and sometimes in pregnancy. Sometimes the disease is caused by a viral infection. In this disease, the bone marrow so damaged or diseased that it shows a decline in the production of red cells, white cells and platelets.

Antibiotics and other medications

Induced bone marrow aplasia around 1960-1970 deaths sometimes through the use of a particular type of antibiotics: chloramphenicol. It is a broad-spectrum antibiotic that is still used, but especially at the time was very popular because of its low price. Also, with the use of a cytostatic agent, a form of chemotherapy, bone marrow aplasia may occur. The drug procainamide sometimes prescribed to include atrial fibrillation is also a cause. Usually, bone marrow aplasia in the use of these medications temporary and disappears again after being stopped thereof. While there used to be deaths occurred through the use of chloramphenicol, this risk is now virtually eliminated by better medical supervision. Also, in certain chemotherapies the operation of the bone marrow is monitored carefully.

X-ray and radiation

People who have been exposed to high doses of X-rays or radioactive rays have an increased risk of bone marrow aplasia. Nowadays it is becoming less and less X-rays used for X-rays due to improved equipment, but it is a reasonably high X-ray doses used in the treatment of cancer. Exposure to radiation by breathing contaminated air or eating contaminated food increases the risk. With nuclear disasters there is a lot of radiation released, which is very harmful for health.


A first phenomenon is part of the typical symptoms of anemia. This is because there also occurs actually anemia: There is a too low content of hemoglobin in the blood, that the oxygen binds to itself. Anemia is a result of bone marrow aplasia, anemia so does not cause bone marrow aplasia. The following symptoms occur in bone marrow aplasia for:
  • Fatigue
  • Faster bleeding, bleeding difficult to stop, bleeding gums
  • Rapid heartbeat or irregular heartbeat
  • Shortness of breath or tightness
  • Point Bleeding under the skin and unexplained bruising
  • Pale skin, discoloration of the lips and mucous membranes
  • Headaches and dizziness
  • Cold extremities
Not all symptoms need to come simultaneously. In addition, having these symptoms is not always due to bone marrow aplasia. Other diseases can cause these symptoms. For the diagnosis will require extensive research. Research is composed of blood test which considers whether there are enough red and white blood cells are present in the blood. The bone marrow is examined by means of a bone marrow biopsy.

Treatment and recovery

Important in bone marrow aplasia is the prevention of infections because the immune system is greatly reduced. Medications may be prescribed as a function of the occurrence of inflammation. A blood transfusion is sometimes necessary. Another method is the administration of antithymocyte globulin, a purified animal protein of horses or rabbits. The horse or rabbit receives blood from the patient is injected, after which the antibodies against this is to create. The antibodies with the blood is then collected from the animal, modified, and again injected into the patient. The antibodies destroy the T-Lymphocytes, which are responsible for degradation of the own stem cells. An intricate process, but for the majority of patients, this method works. However, caution is required: During this treatment's own defenses strongly decreases.
Sometimes it is selected for treatment with male sex hormones. The production of blood sheets can therefore be stimulated. In severe cases, is selected for bone marrow transplantation or stem cell transplantation.
When the disease is temporary due to drugs or otherwise, the cause could be addressed, the treatment of bone marrow aplasia will catch on much faster. When the cause is not found or when too late to intervene this disease can be fatal. If symptoms persist as described above must always be checked by a doctor.