'White feet? Do not treat! " This opinion has been pretty well established by veterinarians and kennel in English, but is still too little known in the Netherlands and Belgium. It means something like "White feet? Do not treat! ", And this then meant that dogs may be due to the so-called MDR1-defect are hypersensitive to certain drugs. I will explain how this works.
For example, the central nervous system is protected by the so-called blood-brain barrier. This system, in that substances from the blood to the cerebrospinal fluid by lets go, ensures that "wrong" materials are directly pumped back into the blood and thus can not reach the important nervous tissue. If this 'pump' does not work properly, are substances not warded toward the centtrale nervous system, potentially life-threatening consequences.
The result is that your dog may react totally wrong on standard tools used by the vet. Affected animals may show the following signs or symptoms: drunken gait, weakness in the legs, loss of orientation, salivation, unconsciousness, muscle tremors and pupillary dilation, at worst, followed by death.
In the Netherlands, at least clinical cases with Scottish shepherds known. Also in related breeds like Border Collie, Bearded Collie and Old English Sheepdog is the condition. The defective gene is also found in the German Shepherd, the Swiss White Shepherd and Collie crosses with blood. Similar research in the United States have led to other hit, but here as well as unknown races: Englisch Shepherd, the long-haired Whippet, McNab and the silken windhound.
Some modern drugs have been tested on sensitive dogs. Other agents base their data on studies in other species. Your vet will undoubtedly inform about this. To prevent accidents, but also to all dogs of a risicoras who do not have the disorder good mediiμciijnen unnecessary to remember, it is recommended to through to solidify once boedonderzoek determine whether your dog might be carrier or sufferer.
Then, without any doubt whether your dog is at risk with the use of certain medications. The results of the research can be incorporated into the pet passport, possibly with a copy of the results and / or English explanations, so that treatment abroad is secure.
White feet, beware! Everything about the MDR1-defect