White feet, beware! Everything about the MDR1-defect

Nature cambarrie August 7, 2016 3 4
'White feet? Do not treat! " This opinion has been pretty well established by veterinarians and kennel in English, but is still too little known in the Netherlands and Belgium. It means something like "White feet? Do not treat! ", And this then meant that dogs may be due to the so-called MDR1-defect are hypersensitive to certain drugs. I will explain how this works.

The blood-brain barrier

Between the tissues in the body, many substances are transported and exchanged. The most important tissues or organs are protected by Mother Nature well. For example, the brains are under a bony skull the spinal cord is protected by the spinal column and the heart is surrounded by chest. But organs can not only to outside influences but also be screened at liquid level.
For example, the central nervous system is protected by the so-called blood-brain barrier. This system, in that substances from the blood to the cerebrospinal fluid by lets go, ensures that "wrong" materials are directly pumped back into the blood and thus can not reach the important nervous tissue. If this 'pump' does not work properly, are substances not warded toward the centtrale nervous system, potentially life-threatening consequences.

The MDR1-defect

One of the hereditary characteristics which plays an important role in the above process, is the MDR1 gene, or the Multi-Drug Resistant 1 gene. If this gene is incorrectly encoded, there is a deviation in the pumping mechanism. This condition is also known in, for example, the human and the mouse. If the dog fails this there are many substances inadvertently passed the direction of the nervous system.
The result is that your dog may react totally wrong on standard tools used by the vet. Affected animals may show the following signs or symptoms: drunken gait, weakness in the legs, loss of orientation, salivation, unconsciousness, muscle tremors and pupillary dilation, at worst, followed by death.

Risk Races

Some breeds, especially among the Collie-like, appear more susceptible to this condition, the MDR1-defect. In Germany, Austria and Switzerland there has been a large study involving 750 dogs are tested. This study showed that three-quarters of the tested Scottish Sheepdogs, about 50 percent of the tested Shetland Sheepdogs and approximately 30 percent of the tested Australian Shepherds with this condition were afflicted. Indeed, there's walk breeds with white feet!
In the Netherlands, at least clinical cases with Scottish shepherds known. Also in related breeds like Border Collie, Bearded Collie and Old English Sheepdog is the condition. The defective gene is also found in the German Shepherd, the Swiss White Shepherd and Collie crosses with blood. Similar research in the United States have led to other hit, but here as well as unknown races: Englisch Shepherd, the long-haired Whippet, McNab and the silken windhound.

The significance for your dog

If you have a dog of one of the above varieties, there is a chance that your dog is a carrier or sufferer of this condition. Other breeds could contain the problem. The hypersensitivity to certain agents occurs only in animals that are homozygous for the recessive gene, that means that both parents of these animals have at least a carrier of the defect. If the animal is heterozygous, then adverse effects on the basis of the MDR1-defect unlikely, but not to exclude out of one hundred per cent.
Some modern drugs have been tested on sensitive dogs. Other agents base their data on studies in other species. Your vet will undoubtedly inform about this. To prevent accidents, but also to all dogs of a risicoras who do not have the disorder good medii╬╝ciijnen unnecessary to remember, it is recommended to through to solidify once boedonderzoek determine whether your dog might be carrier or sufferer.
Then, without any doubt whether your dog is at risk with the use of certain medications. The results of the research can be incorporated into the pet passport, possibly with a copy of the results and / or English explanations, so that treatment abroad is secure.